Hamlet Pharma and SelectImmune Pharma merge to create an innovative pharmaceutical company with a broad and strong portfolio of projects for the treatment of cancer and infections, an additional pharmaceutical project with patent rights for the treatment of tuberculosis is acquired.
Hamlet Pharma provides new therapeutic solutions for targeting and killing tumor cells with greater precision.
Hamlet Pharma provides new therapeutic solutions for targeting and killing tumor cells with greater precision.
Our drug candidate Alpha1H kills tumor cells quickly and selectively. The strong effects have been validated in cell models, animal models and in treated patients, where the response can be measured already within a few hours.
Each year, around 500,000 patients worldwide are diagnosed with bladder cancer, and this number is rising. Alpha1H has been shown to kill tumor cells and significantly reducing tumor size, without harming healthy tissues, with low side effects in patients. Our clinical trials program is now moving towards Phase III.
Early studies in animal models have shown that infusion of Alpha1H into the brain markedly delayed the progression of tumors. In a collaboration with Neurochase Ltd. in the UK, Alpha1H is now tested further to evaluate its potential of treating brain tumors, using proprietary method and technology of administrating drugs locally, with great precision, into the brain.
Source: Diffuse Midline Gliomas Diagnosis and Treatment, by the National Cancer Institute.
BAMLET is a protein-complex formed by alpha lactalbumin from cow’s milk, and oleic acid. Like Alpha1H, BAMLET effectively kills cancer cells and has shown effects against growing tumor tissue. The company intends to establish production of BAMLET primarily for clinical studies for the treatment/prevention of colon cancer in the gastrointestinal tract and oral cancer in the oral cavity.
Colorectal cancer is a leading cause of death world-wide and more than 180,000 cases are diagnosed annually in the US alone. Daily, long-term treatment with BAMLET in the drinking water inhibits intestinal tumor development in mice genetically susceptible to intestinal tumors. Target groups for BAMLET treatment are patients at risk of developing colon cancer and patients who already have the disease.
Hamlet Pharma intends to investigate whether BAMLET can be developed into a treatment for oral cancer.
A research group in Lund, led by Professor Catharina Svanborg discovered in 1995 that a component of human breast milk kills tumor cells without harming mature, healthy cells.
Since the discovery, the research team has successfully worked to characterize the HAMLET structure, its mechanisms and treatment effects in animal models and in patients. HAMLET´s tumor killing abilities have since the discovery been confirmed by several international research groups working on different aspects of HAMLET.
The results have been published in prestigious journals like The New England Journal of Medicine, GUT, Nature Communication and PNAS (Proceedings of the National Academy of Science, USA).
2021
A scientific journey from discovery to validation of efficacy in cancer patients: HAMLET and alpha1-oleate
Bladder cancer therapy without toxicity—A dose-escalation study of alpha1-oleate
The discovery of HAMLET defines a new class of cancer drugs with broad effects against cancers of different origin and a high degree of selectivity. HAMLET’s aim is to prove the efficacy of HAMLET therapy and to develop drugs that kill tumour cells with greater precision than current drugs.
